Author/Authors :
Gaibar, María European University of Madrid - Department of Basic Medical Sciences, Spain , Arqués, Meritxell University of Barcelona - Faculty of Biology - Section of Anthropology, Spain , Fernández-Santander, Ana European University of Madrid - Department of Basic Medical Sciences, Spain , Novillo, Apolonia European University of Madrid - Department of Basic Medical Sciences, Spain , Romero-Lorca, Alicia European University of Madrid - Department of Basic Medical Sciences, Spain , Li, Qi wei European University of Madrid - Department of Basic Medical Sciences, Spain , Esteban, M. Esther University of Barcelona - Faculty of Biology - Section of Anthropology, Spain
Abstract :
This review is focused on the genetic variation of sulfotransferases (SULTs) and cytochromes (CYPs) genes among different ethnic groups, mainly focusing in variation in North African populations. Polymorphisms of SULTs and CYPs proteins are associated with altered enzymatic activity and physical characteristics. Single nucleotide polymorphisms (SNP) in these genes have shown relevant ethnic differences among Sub-Saharan African and European groups that might contribute to understand the variability in drug metabolism and risk to certain cancers that has been described among these two groups.
