HYPOADIPONECTINEMIA AND DYSLIPIDEMIA IN RELATION TO GLYCEMIC STATUS IN TYPE 2 DIABETES AND CORONARY HEART DISEASE

OBJECTIVE: to study the relationship of adiponectin level with lipid profile and glycemic control in type 2 diabetic subjects with and without coronary heart disease (CHD).METHODOLOGY: This cross-sectional/ analytical study consisted of three groups. Group A consisted of 60 healthy subjects, group B consisted of 60 type 2 diabetic subjects and group C consisted of 60 type 2 diabetic subjects with coronary heart disease. The study participants were analyzed for serum adiponectin level, triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c).RESULTS: Significantly high adiponectin level was observed in female subjects as compared to male subjects. Type 2 diabetic subjects with and without coronary heart disease presented with significantly higher FBG, HbA1c, TC and TG (p value 0.05) and significantly lower levels of serum adiponectin and HDL-C (p value 0.001). Adiponectin level showed significant positive association with HDL-C in control group (female: r 0.988; p= 0.01, male: r 0.948; p= 0.01), type 2 diabetic group (female: r 0.908; p= 0.01, male: r 0.860; p= 0.01) and type 2 diabetic group having coronary heart disease (female: 0.775; p= 0.01,male: 0.650; p= 0.01). Significant (p value 0.01) negative association of adiponectin was observed with TG, FBG and HbA1c in type 2 diabetic subjects with and without coronary heart disease.CONCLUSION: Hypoadiponectinemia in type 2 diabetic subjects with and without coronary heart disease is related with un-controlled glycemic status and dyslipidemia.