Author/Authors :
Qaiser, Fatima National University of Sciences and Technology - Army Medical College - Department of Biochemistry and Molecular Biology, Pakistan , Naveed, Abdul Khaliq Riphah International University, Al-Mizan Campus - Islamic International Medical College, Pakistan , Sadiq, Sarah National University of Sciences and Technology - Army Medical college - Department of Biochemistry and Molecular Biology, Pakistan , Waheed, Palvasha National University of Sciences and Technology - Army Medical college - Department of Biochemistry and Molecular Biology, Pakistan , Muhammad, Iqbal Army Medical college - Department of Histopathology, Pakistan , Younis, Rubina Army Medical college - Department of Histopathology, Pakistan , Hashmi, Shoaib Naiyar Combined Military Hospital - Armed Forces Institute of Pathology - Department of Histopathology, Pakistan
Abstract :
OBJECTIVES: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. METHODS: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast cancer tissue specimens. All the cases included were diagnosed at stage II of disease. c2 tests and Regression analysis were carried out to determine the correlation between histopathological parameters and expression pattern of CK2α RESULTS: There was a positive correlation between total as well as nuclear expression of CK2α with increasing Nottingham prognostic index (p 0.0001). CK2α was also found to be significantly associated with the lymph node metastasis (p 0.0001). CONCLUSION: Immunohistochemical expression of CK2α can be used as an indicator of poor prognosis of disease even if overall stage of the breast cancer is the same. CK2α can also serve to predict the aggressiveness of the breast cancer as well and can identify the sub set of patients at high risk of developing lymph node metastasis.
Keywords :
CK2alpha protein (MeSH) , Nottingham prognostic index (Non , MeSH) , Immunohistochemistry (MeSH) , Prognosis (MeSH) , Breast cancer (MeSH) , Neoplasm Metastasis (MeSH)
