Ammonium Chloride as a Potential Candidate for the Treatment and Controlling of Covid-19

Dear Editor, Coronaviruses are pathogens with a zoonotic potential which are positive sense single-stranded RNA viruses. SARS Coronavirus-2, the cause of Covid-19 infection, is from the betacoronavirinea subfamily, which has close genomic and proteomic similarity to SARS Coronavirus-1 [1]. Given the genomic proximity of these two viruses, studies on SARS Coronavirus-1 can be used to control or detect SARS Coronavirus-2. The cellular receptor of the virus is ACE-II, which virus binds to it through S protein [2]. S Protein plays a major role in the pathogenesis of the virus by reducing the levels of the ACEII receptor in the infected cells, disrupting the renin-angiotensin system and affecting the tropism. Therefore, S protein is one of the important proteins in the pathogenesis of the virus and is an appropriate target for treatment [3, 4].