Acute fulminant cholestatic jaundice in sickle cell disease

Liver patients with sickle cell disease (SCD) are subjected to many insults. Hepatic injury, which might be caused by the sickling process, blood transfusion complications (viral hepatitis or iron overload) or drug toxicity. Sickle cell hepatopathy is quit complex and distinguishing between different types of syndromes is difficult. In this paper we report on three SCD patients who presented with sickle cellintrahepatic cholestasis (SCIC) (fever, leukocytosis, coagulopathy, and extreme hyperbilirubinemia). The literature on sickle cell-associated liver diseases is reviewed.