Author/Authors :
Bian, Xiaohui China Medical University - Shengjing Hospital - Department of Nephrology, China , Liu, Na China Medical University - Shengjing Hospital - Department of Nephrology, China , Bai, Yu China Medical University - Shengjing Hospital - Department of Nephrology, China , Zheng, Liqiang China Medical University - Shengjing Hospital - Department of Clinical Epidemiology, China , He, Ping China Medical University - Shengjing Hospital - Department of Nephrology, China , Su, Xuesong China Medical University - Shengjing Hospital - Department of Nephrology, China , Du, Feng China Medical University - Shengjing Hospital - Department of Nephrology, China , Yang, Xu China Medical University - Shengjing Hospital - Department of Nephrology, China , Li, Detian China Medical University - Shengjing Hospital - Department of Nephrology, China
Abstract :
Introduction. Prior studies evaluating the relationship between leptin and outcomes in chronic kidney disease patients have shown conflicting results. Our aim was to evaluate the association of serum leptin with all-cause and cardiovascular disease (CVD)-related mortality in stable maintenance hemodialysis patients. Materials and Methods. We carried out an observational prospective cohort study of 53 patients on maintenance hemodialysis. The follow-up period was 5 years. Leptin levels were measured at baseline before the start of a hemodialysis session. Proportional hazards models were used to evaluate the relationship between leptin and all-cause and CVD-related mortality. Results. During the follow-up period, 26 patients (49.1%) died. Fifteen of 26 deaths (57.7%) were attributable to CVD. Cox proportional hazards analysis showed that a leptin level equal to or greate than the median value (3.45 ng/mL) was associated with lower mortality rates (hazard ratio, 0.211; 95% confidence interval, 0.062 to 0.723; P = .01) after multivariable adjustment for potential confounders. However, leptin was not an independent risk factor for CVD-related mortality. Conclusions. There was a converse association between the serum leptin concentration and mortality in stable maintenance hemodialysis patients. Low serum leptin concentration is an independent risk factor of all-cause mortality in stable maintenance hemodialysis patients, but may not be linked with CVD-related mortality.
