Re: Lovastatin for Reduction of Leptin in Nondialysis Patients With Type 2 Diabetic Nephropathy

Dear Editor, We read with interest the article in the Iranian Journal of Kidney Diseases, by Gholamin and colleagues, “Lovastatin for Reduction of Leptin in Nondialysis Patients With Type 2 Diabetic Nephropathy.” There is controversy regarding leptin and vascular endothelial function. Leptin induces endothelium-dependent vascular relaxation by stimulating nitric oxide (NO). However, some believe that the leptin-induced vasodilatation is independent on NO and other vasoactive agents such as endothelium-derived hyperpolarizing factor (EDHF) or prostacyclins are possibly involved.