Author/Authors :
Farhadieh, R. D. Yale University - Departmenls of Radio-Oncology Surgery, USA , Smee, R. Yale University - Departmenls of Radio-Oncology Surgery, USA , Salardini, A. Yale University - Departmenls of Radio-Oncology Surgery, USA , Yang, J. L. Yale University - Departmenls of Radio-Oncology Surgery, USA , Ow, K. Yale University - Departmenls of Radio-Oncology Surgery, USA , Russell, P. J. Yale University - Departmenls of Radio-Oncology Surgery, USA
Abstract :
Background: Oral squamous cell carcinoma is the sixth most common malignancy in the world today. ING] b/pJJ is a newly-discovered tumor suppressor which enhances p5J activity. Transfer of pJJ protein from nucleu s to cytoplasmic compartment has been previously report ed in leukemias. The objective of this study was to determine the correlation between pJJin gl b cytoplasmic transfer and lymph node meta stasis in oral squamous cell carcinoma. Methods: Fifty seven patient streated with surgery alone or surgery and adjuvant radiotherapy for primary oral squamous cell carcinoma were enrolled into this study. Immunohistochemi cal express ion of all of the above-mentioned markers was studied. Results: Analysis of the sections demonstrated that p5J and MDM2 were expressed in 45.6% and 68.4% of patients, respectively. pJJING l b nuclear expression was completely absent while cytoplasmic translocation was noted in 78.9% of cases. Positive cytoplasmic expression of pJ JINGJ b correlated with increased risk of lymphat ic metastasis (p=O.04). No further correlation with overall disease recurrence or survival was noted. Conclusion: Apparently, pJJ ING Ib cytoplasmic transfer correlates with lymph node metastasis in oral squamous cell carcinoma.
