Author/Authors :
Zolghadri, Jaleh shiraz university of medical sciences - Department of Obstetrics and Gynecology, شيراز, ايران , Tavana, Zohreh shiraz university of medical sciences - Department of Obstetrics and Gynecology, شيراز, ايران , Alborzi, Saeed shiraz university of medical sciences - Department of Obstetrics and Gynecology, شيراز, ايران , Kazerooni, Talie shiraz university of medical sciences - Department of Obstetrics and Gynecology, شيراز, ايران
Abstract :
Background: Recurrent abortion is defined as three or more consecutive pregnancy losses. We aimed to determine the relationship between male sperm parameters and hypo-osmotic swelling score and recurrent abortion. We also studied whether washing of spermatozoa and intrauterine insemination in patients with recurrent miscarriage and low score hypoosmotic swelling test in male partners could improve the outcome of pregnancy. Methods: Between February 2003 and September 2006 in gynecology clinics affiliated to Shiraz University of Medical Sciences, 176 women with a history of recurrent abortion and their male partners were selected as study group. And 159 healthy and fertile couples without a history of recurrent abortion were selected as control group. The relationship between male sperm parameters and hypo-osmotic swelling test and recurrent spontaneous abortion in their female partners was evaluated after intrauterine insemination for those with abnormal hypo-osmotic swelling test. Outcome of pregnancy in patients with recurrent abortion whose male partners had low score hypo-osmotic swelling test was evaluated after intrauterine insemination. Results: Low scores of hypo-osmotic swelling test were more frequently seen in the study group than the controls: 116 (65%) versus 24 (15%). The mean hypo-osmotic swelling score was significantly lower in the study group (P 0.001). The outcome of pregnancy improved after intrauterine insemination in those with low score hypoosmotic swelling test. The pregnancy success rate in the treated group (pregnant with intrauterine insemination) was 77.77% while in the untreated group (pregnant without intrauterine insemination) was 30.76% with a success rate ratio of 2.04. Conclusion: There was a positive relationship between low hypo-osmotic swelling test score in male partners and recurrent abortion in their wives. Intrauterine insemination improved the outcome of pregnancy in these couples.
