Author/Authors :
Kota, Sunil Kumar Medwin Hospital - Department of Endocrinology, India , Meher, Lalit Kumar MKCG Medical College - Department of Medicine, India , Rao, Epari Sanjeeva KIMS Research Foundation - Department of Pathology, India , Jammula, Sruti Roland Institute of Pharmaceutical Sciences - Department of Pharmaceutics, India , Kota, Siva Krishna Central Security Hospital - Department of Anaesthesia, Saudi Arabia , Modi, Kirtikumar D Medwin Hospital - Department of Endocrinology, India
Abstract :
There is a plethora of biomarkers proposed and being researched in the field of sepsis. The complex pathophysiology of sepsis involves many mediators of inflammation pertaining to coagulation, complement, contact system activation, inflammation, apoptosis, etc. Markers related to those processes can gauge the degree of sepsis. Compared with localized pathology, the systemic nature and involvement of multiple organs in sepsis gives scope for numerous potential biomarkers. There is no gold standard for the diagnosis of sepsis. Currently available/in-research biomarkers are compared for their efficacy with methods used to diagnose and monitor sepsis such as combination of clinical signs and available laboratory variables. An arbitrary classification of these biomarkers is made and the literature surrounding these markers and their efficacy in diagnosis of sepsis is reviewed.
