Author/Authors :
Pasupathi, Palanisamy Postgraduate Medical Institute,Institute of Laboratory Medicine - K G Hospital , Chinnaswamy, Palanisamy Institute of Laboratory Medicine - Kovai Medical Center and Hospital , Saravanan, Ganesan Annamalai University - Faculty of Science - Department of Biochemistry and Biotechnology , Senthil Kumar, Utharasamy Institute of Laboratory Medicine, Bio Line Research Institute, India
Abstract :
The effect of chronic cigarette smoking on lipid peroxidation and antioxidant status in 100 newlydiagnosed patients with gastric cancer was studied. Equal number of age- and sex-matched healthycontrol subjects was taken as control. The level of plasma and erythrocyte thiobarbituric acid reactivesubstances (TBARS) was markedly increased in both the gastric cancer patients when compared tocontrol subjects. The activities of enzymatic and non-enzymatic antioxidants were significantlydecreased in both (smokers and non-smokers) gastric cancer groups when compared to controlsubjects. Comparatively, the increased TBARS level and decreased antioxidants level was observed insmokers than non-smoking gastric cancer patients. The present study highlights the occurrence of lipidperoxidation and possible breakdown of antioxidant status in cigarette smoking, which may subsequently increase the possibility of initiation and progression of gastric cancer.
