Author/Authors :
Rezaul Karim, Md. Islamic University - Department of Applied Nutrition and Food Technology, Bangladesh , Haque, Abedul Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Islam, Khairul Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Ali, Nurshad Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Abdus Salam, Kazi Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Alam Saud, Zahangir Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Hossain, Ekhtear Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Fajol, Abul Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh , Akhand, Anwarul Azim Dhaka University - Department of Genetic Engineering and Biotechnology, Bangladesh , Himeno, Seiichiro Tokushima Bunri University - Faculty of Pharmaceutical Sciences - Laboratory of Molecular Nutrition and Toxicology, Japan , Hossain, Khaled Rajshahi University - Department of Biochemistry and Molecular Biology, Bangladesh
Abstract :
The present study was undertaken to evaluate the protective effect of turmeric powder on arsenictoxicity through mice model. Swiss albino male mice were divided into four groups. The first groupwas used as control, while groups 2, 3, and 4 were treated with turmeric powder (T, 50mg/kg bodyweight/day), sodium arsenite (Sa, 10mg/kg body weight/day) and turmeric plus Sa (T+Sa),respectively. Results showed that oral administration of Sa reduced the weight gain of the micecompared to the control group and food supplementation of turmeric prevented the reduction of weightgain. Turmeric abrogated the Sa-induced elevation of serum urea, glucose, triglyceride (TG) level andalanine aminotransferase (ALT) activity except the activity of alkaline phosphatase (ALP). Turmericalso prevented the Sa-induced perturbation of serum butyryl cholinesterase activity (BChE). Therefore,ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric toreduce or to prevent arsenic toxicity in human.
