Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms inChronic Rhinosinusitis

Introduction:IL-8 is one of the pro-inflammatory cytokines which can play an essentia I role in the pathogenesis ofchronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producingIL-8 is partially determined by IL-8-251 Arr polymorphism. Hence, the aim of the present study wasto investigate the association between IL-8-251 Aff and CXCR2 +1208CIT genes polymorphisms andsusceptibility to CRS and NP.Materials and Methods:Two hundred and forty fiveCRS patients and 204 healthy controls were included in this study. CRSpatients were categorized by the existence or absence of NP. IL-8 promoter-251 A/T and CXCR2+1208 crr gene polymorphisms were genotyped via the allele specific PCR (AS-PCR) method.Results:While no remarkable difference was demonstrated between patients and controls for both CXCR2+1208 crr and IL-8 -251 Aff polymorphisms, a significant increase in IL-8-25 I AA genotype wasdetected in CRS patients with NP compared to those without it (29.3% and 16.2%, respectively;P=O.03). Interestingly, this association got far stronger when only non-asthmatic CRS patients weretaken into cons ideration (P=O.OO I).Conclusion:The results of the present study indicate that the inheritance of IL-8-251 Aalle Ie is associatedsignificantly with NP development in CRS patients. Therefore, NP formation might be a result of theexposure to an intense inflammatory environment, which is more likely in genetically susceptible CRSpatients.Keywords:Chronic rhinos inusitis, CXCR2, InterleukinL-8, Nasal polyposis, Polymorphism