Design of alternating magnetic field generator for magnetic fluid hyperthermia research application

Hyperthermia utilizing nanoparticles is a novel cancer therapy, which relies on the heat released when nanoparticles inside a tumor are exposed to an alternating magnetic field. The field strength and frequency as the main variants affect performance of nanoparticles in heat generation. Besides characteristics of the nanoparticle, which are the main criteria for tuning amplitude and frequency of the magnetic field generated by an Alternating Magnetic Field Generator (AMFG), several related parameters should be considered for an optimum design of AMFG. These parameters are input voltage range, copper tube resistance used in solenoid coil, coil number of turns, etc. With regard to these criteria, a design procedure of AMFG for research applications is proposed to maximize the heat released by nanoparticles. In order to validate the design, an experimental setup of AMFG is prepared, which is used for in vivo hyperthermia tests. The experimental results are shown and compared with the simulations.