Chronic Allograft Nephropathy

A 50-year old female with a history of chronic kidney disease secondary to polycystic kidney disease underwent a living unrelated renal transplant on 8th March, 2001 after a short period on hemodialysis. Initial immuno­supressive regimen included prednisone, cyclosporine and mycophenolate mofetil (MMF).The course of the patient was complicated by acute rejection one week after transplantation, which was treated with intravenous methyl prednisolone and a short course of anti­thymocyte globulin followed by modification of the immunosuppressive regimen to pre­dnisone, tacrolimus and MMF. Serum creatinine levels decreased to a nadir of 70 µmol/L.