Detection of anti-Myalin and anti-axonal auto-antibodies in Iraqi patients with multiple sclerosis

Multiple Sclerosis (MS) is characterized by demyelination of different parts of the central nervous system (CNS) leaving scars (sclerosis) which leaves the neuron and the axis highly attenuated. It is one of the most important inflammatory diseases of the CNS that causes deficits with the progression of neurological disease. This study included 65 MS patients (37 relapsing-remitting (RR), 21 secondary-progressive (SP), 7 primary-progressive (PP) and 50 apparently healthy individuals controls. The results showed low level of autoantibodies to myelin associated glycoprotein (anti-MAG) in MS patients, while anti-axon antibodies had high level. This means that the production of these auto-antibodies in different stages of the disease increase its effect in the diagnosis and the possibility that it had some role in the progress and development of MS, so the use of anti axonal antibodies test in the diagnosis is an important marker.