Author/Authors :
Mohammadi sichani, Mehrdad isfahan university of medical sciences - School of Medicine - Department of Urology, اصفهان, ايران , Sarreshtedar Yazdi, Fateme isfahan university of medical sciences - School of Medicine - Department of Pathology, اصفهان, ايران , Afshar Moghaddam, Noushin isfahan university of medical sciences - School of Medicine - Department of Pathology, اصفهان, ايران , Chehrei, Ali isfahan university of medical sciences - School of Medicine - Department of Pathology, اصفهان, ايران , Kabiri, Mahmud isfahan university of medical sciences - School of Medicine - Department of Urology, اصفهان, ايران , Naeimi, Amin yazd university - School of Humanities - Department of English, يزد, ايران , Taheri, Diana isfahan university of medical sciences - School of Medicine - Department of Pathology, اصفهان, ايران
Abstract :
The Insulin-Like growth factor-I receptor (IGF-IR), a tyrosine-kinas receptor over expressed in many tumor cell lines and in some human tumors, plays a critical role in transformation, tumorigenicity and metastasis. The aim of the present study is to investigate the role of IGF-IR expression as a prognostic factor in RCC. This study was conducted in a historical cohort of 82 patients who had RCC treated with radical nephrectomy from 1994 to 2005. Specimens were reevaluated with regard to histological subtype, nuclear grade, stage and IGF-IR expression. The IGF-IR stain was semi- quantitatively evaluated using the Allred score system. Kaplan-Meier analysis demonstrated a significant positive correlation between Fuhrman nuclear grade and IGFIR Allred score (P 0.0001). Survival in patients with score IGF-I legsland 4 was 90.21 month and in patients with score IGF-1R 4 was 33.39 month (P Value 0.0001). Cox regression analysis indicated that expression of IGF-IR is a prognostic factor in patients with RCC (P Value 0.0001, odds Ratio = 2.38). In conclusion, a statistically significant correlation was demonstrated between IGF-IR expression and Fuhrman nuclear grading and survival in patients with RCC. In stage-bystage and grade-by-grade analysis; however, it seems that we cannot consider IGF-IR as an independent prognostic factor.
