Author/Authors :
Fatma, Lilia Ben La Rabta Hospital, and Laboratory of Kidney Pathology - Department of Nephrology, Tunisia , Barbouch, Samia Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Fethi, Ben Hamida Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Imen, Ben Abdallah Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Karima, Khiari Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Imed, Helal Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Fethi, El Younsi Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Fatma, Ben Moussa La Rabta Hospital - Laboratory of Kidney Pathology - Department of Nephrology, Tunisia , Rim, Goucha Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia , Taieb, Ben Abdallah Laboratory of Kidney Pathology - Charles Nicolle Hospital - Department of Nephrology and Internal Medicine, Tunisia , Maiz, Hedi Ben La Rabta Hospital - Laboratory of Kidney Pathology - Department of Nephrology, Tunisia , Adel, Khedher Charles Nicolle Hospital - Laboratory of Kidney Pathology - Department of Nephrology and Internal Medicine, Tunisia
Abstract :
Brown tumors are unusual but serious complications of renal osteodystrophy. We retrospectively studied 12 patients presenting with chronic renal failure and brown tumor related to secondary hyperparathyroidism. Eleven patients were on chronic hemodialysis. The median duration between renal failure and end stage renal failure was 36 months (range: 12-190 months) and the median duration in dialysis for 11 cases: 92 months (range: 72-252 months). The bone pain was noted in all cases (100%), pathological fracture in one case (8%) and a palpable bone tumor in 10 cases (83%). Elevated serum Calcium ( 2.35 mmol/L) was noted in four cases (33%), elevated serum Phosphate ( 1.78 mmol/L) in ten cases (80%), elevated serum Alkaline Phosphate ( 290 UI/L) in all cases and intact PTH was 300 pg/mL in all cases with a serum median rate at 1475 pg/mL (range: 682-3687 pg/L). Subtotal parathyroidectomy was performed in all cases with a resultant decrease in size of brown tumors. We report here patient with CKD with unusual frequency and variable locations. This may be attributed tothe lack of the new calcium free phosphate binders and calcimimetics.
