Author/Authors :
Abdel Halim, Medhat Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait , Al-Otaibi, Torki Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait , Al-Waheeb, Salah Mubarak Al-Kabeer Hospital - Histopathology Department, Kuwait , Abdel Tawab, Khaled Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait , El-Kholy, Osama Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait , Nair, Prasad Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait , Said, Tarek Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait , Nampoory, M. R. Narayanan Ibn Sina Hospital - Hamed Alessa Organ Transplantation Center, Kuwait
Abstract :
Acute Antibody Mediated Rejection (AMR) is rarely reported as a long-term complication of renal transplantation, and it can present on top of another chronic pathology affecting the graft. A 45-year-old gentleman with chronic kidney disease due to unknown etiology received renal transplantation from his sister with 4 HLA mismatches. He received antithymocte globulin induction therapy and was maintained on steroids, azathioprine (AZA) and cyclosporine A (CsA). Up to eight years post-transplantation he was clinically and biochemically stable. He lost followup for about one year, and then presented with nephritic nephrotic syndrome and rise of serum creatinine (SCr.) to 210 μmol/L. Graft biopsy revealed picture suggestive of acute AMR on top of de novo membranoprolipherative glomerulonephritis (MPGN) with focal crescent formation, diffuse immune complex deposition and peri-tubular capillaries C4d positivity. Anti-HLA donor specific antibodies were highly positive for B and T cells class I and class II. The patient was treated with intravenous immunoglobulin, plasma exchange and anti-CD20 (rituximab). AZA was changed to mycophenolate mofetil and CsA to tacrolimus. He had partial response, but SCr. continued at 220 μmol/L.
