Author/Authors :
Dhakal, Subodh Sagar B. P. Koirala Institute of Health Sciences - Department of Internal Medicine, Nepal , Sharma, Sanjib Kumar B. P. Koirala Institute of Health Sciences - Department of Internal Medicine, Nepal , Bhatta, Narendra B. P. Koirala Institute of Health Sciences - Department of Internal Medicine, Nepal , Bhattarai, Sabina B. P. Koirala Institute of Health Sciences - Department of Dermatology and Venereology, Nepal , Karki, Smriti B. P. Koirala Institute of Health Sciences - Department of Pathology, Nepal , Shrestha, Shailendra B. P. Koirala Institute of Health Sciences - Department of Internal Medicine, Nepal , Rijal, Suman B. P. Koirala Institute of Health Sciences - Department of Internal Medicine, Nepal , Karkil, Prahlad B. P. Koirala Institute of Health Sciences - Department of Internal Medicine, Nepal
Abstract :
To determine the clinical profile and patterns of lupus nephritis patients in Eastern Nepal,we studied 38 patients fulfilling the 1982 revised criteria of American College of Rheumatology for systemic lupus erythematous (SLE),followed up from January 2004 to January 2008. Arthritis was a common initial feature in addition to variable cutaneous,cardiac,pulmonary and neuropsychiatric manifestations. Renal biopsy showed grade 1 changes in 5 (13.5%) patients,grade 2 changes in 13 (35.1%) patients,grade 3 changes in 9 (24.3%) patients,grade 4 changes in 7 (18.9%) patients,grade 5 changes in 2 (5.4%) patients,and grade 6 changes in 2.7% patients. Antinuclear antibody (ANA) assay and anti-ds DNA were positive in 78.4 and 81.1%,respectively. We conclude that mesangial proliferative glomerulonephritis (grade 2) was the most common pattern of lupus nephritis encountered in our study. Timely diagnosis and treatment may improve the overall patients survival.
