Title of article
Drug interaction between rifampicin and sirolimus in transplant patients
Author/Authors
Ngo, B. T. University of Cape Town - Groote Schuur Hospital, Medical Research Council, Liver Research Centre - Departments of Surgery and Medicine, Transplant Unit, South Africa , Pascoe, M. University of Cape Town - Groote Schuur Hospital, Medical Research Council, Liver Research Centre - Departments of Surgery and Medicine, Transplant Unit, South Africa , Kahn, Delawir University of Cape Town - Groote Schuur Hospital, Medical Research Council, Liver Research Centre - Departments of Surgery and Medicine, Transplant Unit, South Africa
From page
112
To page
115
Abstract
We report two cases of drug interaction between rifampicin and sirolimus in renal trans-plant patients who were diagnosed with tuberculosis after transplantation and induction of immuno-suppressive therapy with sirolimus. The dosage of sirolimus had to be increased,in one case up to six-fold and in the second case up to five-fold,to maintain serum levels after starting the rifampicin. The two patients tolerated the treatment well,with no signs of tuberculosis and good renal function.
Journal title
Saudi Journal of Kidney Diseases and Transplantation
Journal title
Saudi Journal of Kidney Diseases and Transplantation
Record number
2675590
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