Author/Authors :
Hamouda, M. Monastir University - Faculty of Medicine, Fattouma Bourguiba Hospital - Department of Nephrology, Department of Epidemiology, Tunisia , Ben Dhia, N. Monastir University - Faculty of Medicine, Fattouma Bourguiba Hospital - Department of Nephrology, Department of Epidemiology, Tunisia , Aloui, S. Monastir University - Faculty of Medicine, Fattouma Bourguiba Hospital - Department of Nephrology, Department of Epidemiology, Tunisia , El Mhamedi, S. University Hospital of Monastir - Faculty of Medicine - Department of Preventive Medicine, Tunisia , Skhiri, H. Monastir University - Faculty of Medicine, Fattouma Bourguiba Hospital - Department of Nephrology, Department of Epidemiology, Tunisia , Elmay, M. Monastir University - Faculty of Medicine, Fattouma Bourguiba Hospital - Department of Nephrology, Department of Epidemiology, Tunisia
Abstract :
We sought to identify predictors of development of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism. The patients were divided into two groups according to their serum calcium (Ca) levels within 24 hours of undergoing para-thyroidectomy: the hypocalcemia group (22 patients) with post-operative serum Ca levels of 2 mmol/L or less,and the normocalcemia group (48 patients),with post-operative serum Ca levels higher than 2 mmol/L. By using multivariate stepwise logistic regression analysis,high pre-operative serum Ca level had the strongest predictive value of development of early hypocalcemia with an adjusted odds ratio (aOR) of 3.01,followed by hypo-albuminemia (aOR = 2.72),younger age (aOR = 2.56),and high pre-operative alkaline phosphatase (ALP) levels (aOR = 2.28). We conclude that among patients with secondary hyperparathyroidism,age,levels of pre-operative serum Ca,ALP and albumin correlate positively with the development of early post-operative hypocalcemia. Patients with one of these factors should be monitored more closely in the early post-parathyroidectomy period.
