Title of article :
DABCO-Catalyzed Easy Access to Benzo[d]naphtho[2,3-g][1,3]-oxazocine‑8,13(6H,14H)‑diones in Aqueous Media
Author/Authors :
Madani Qamsari ، Fatemeh Department of Chemistry - Islamic Azad University, Tehran North Branch , Moradi ، Shahram Department of Chemistry - Islamic Azad University, Tehran North Branch , Foroumadi ، Alireza Department of Medicinal Chemistry - Faculty of Pharmacy Drug Design and Development Research Center, Institute of Pharmaceutical Sciences (TIPS) - Tehran University of Medical Sciences , Mahdavi ، Mohammad Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute - Tehran University of Medical Sciences , Moghimi ، Abolghasem Department of Chemistry - Imam Hossein University
Abstract :
An eco-friendly, highly efficient, and tandem reaction between 2-hydroxy-1,4-naphthoquinone and quinolinium salts in the presence of DABCO, 1,4-diazabicyclo[2.2.2]octane, in aqueous medium is developed for the synthesis of functionalized polycyclic naphthooxazocines. The advantageous features of this operationally simple procedure along with good to excellent yields of products highlighted this method for the preparation of oxazocine. Moreover, the products obtained without the need to column chromatography. In order to reduce the hazards of chemicals and solvents, the reaction was conducted in the green solvent, water. All newly synthesized compounds were characterized by different methods involving IR, 1H NMR, 13C NMR spectroscopy.
Keywords :
Naphthooxazocines , DABCO , Aqueous media , Environmentally benign
Journal title :
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Journal title :
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
