Evaluation of the osteoprotegerin and insulin levels in patient’s serum with hypothyroid and hypothyroid with type 2 diabetes mellitus

The aim of this study: to estimate OPG levels in serum of patients with thyroid disorder and thyroid disorder + type 2 diabetics and the relationship between them. The study was conducted on 105 subjects and they were divided into three groups with these inclusion criteria: 70 thyroid disorders and thyroid diabetes patients (female) and 35 healthy controls. The age range was 18 –45 years. The parameters which have been measured include:-Age, BMI, TT3, TT4, TSH, FBS, Insulin hormone, HOMA-IR and those of the lipid function test. COL, Tg, HDL, VLDL, and LDL. Our results support that hypothyroidism is not the main reason for type 2 diabetes mellitus, but the altered lipid profile in hypothyroid patients is the main implicated in incidence of prediabetes, which represents HOMA-IR resistance and risk for development of type 2 diabetic mellitus. Conclusion Depending on the results obtained during this study, the increase in osteoprotegrine levels in hypothyroid and hypothyroid + type 2 DM is not related to these diseases. In other words, OPG is not legitimately ensnared in hypothyroidism or type 2 diabetic mellitus pathogenesis. Moreover, the disorders in lipid profile levels were legitimately ensnared in hypothyroidism which develops.