Author/Authors :
Sharma, Alok All India Institute of Medical Sciences (AIIMS) - Department of Pathology, India , Gupta, Ruchika All India Institute of Medical Sciences (AIIMS) - Department of Pathology, India , Rizvi, Yasir All India Institute of Medical Sciences - Department of Nephrology, India , Rathi, Shyam All India Institute of Medical Sciences - Department of Hematology, New Delhi , Mahapatra, Manoranjan All India Institute of Medical Sciences - Department of Hematology, India , Bhowmik, Dipankar All India Institute of Medical Sciences (AIIMS) - Department of Nephrology, India , Dinda, Amit K. All India Institute of Medical Sciences - Department of Pathology, India
Abstract :
A young adult was diagnosed to have acute lymphoblastic leukemia,T-cell immunophenotype and was initiated on chemotherapy. He presented with acute renal failure two days after the completion of his induction regimen. A renal biopsy showed features of necrotizing crescentic glomerulonephritis (GN). Serology for c-anti-neutrophil cytoplasmic antibody (ANCA) was positive and a final diagnosis of ANCA-associated necrotizing crescentic GN was made. Aggressive immunosuppression could not be used due to the presence of nosocomial pneumonia and the patient expired 26 days after the renal biopsy diagnosis. We report for the first time the association of acute lymphoblastic leukemia with crescentic GN and,hence,expand the list of malignancy-related ANCA-positive GN.
