Author/Authors :
Bakr, Ashraf Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , Eid, Riham Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , Sarhan, Amr Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , Hammad, Ayman Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , El-Refaey, Ahmed Mahmoud Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , El-Mougy, Atef Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , Zedan, Mohammed Magdy Mansoura University - Mansoura University Children’s Hospital - Pediatric Nephrology and Dialysis Unit, Egypt , ElHusseini, Fatma Mansoura University - Mansoura University Children’s Hospital - Pathology Department, Egypt , Abd El-Rahman, Ashraf Mansoura University - Mansoura University Children’s Hospital - Radiology Department, Egypt
Abstract :
This study retrospectively investigates the indications and results of renal biopsy in children to determine the patterns of childhood kidney disease in a single tertiary children s hospital in Egypt. We included all the patients who underwent ultrasound-guided renal biopsy from 1998 to 2012. All the kidney biopsies were studied under light microscopy,while immunofluorescence and electron microscopy were performed when indicated. A total of 1246 renal biopsies were performed over 15 years,on 1096 patients. The mean age of the patients at the time of biopsy was 9.2±3.7 years. The main indication for a biopsy was the steroid-resistant nephrotic syndrome (n=354,28.4%),followed by the atypical nephrotic syndrome (n=250,20.1%),and renal abnormalities in the systemic diseases (n=228,18.3 %). In the 1226 pathologically diagnosed specimens,primary glomerulonephritis was the most common finding (n=826,67.4%),followed by secondary glomerulonephritis (n=238,19.4%). The most common causes of primary glomerulonephritis were Minimal Change Disease (MCD) (n=267,21.8%),diffuse proliferative glomerulonephritis (n=188,15. 3%),and focal proliferative glomerulonephritis (n=164,13.3%). Lupus nephritis (n=209,17%) was the most common cause of secondary glomerulonephritis. We conclude that the steroid-resistant nephrotic syndrome was the most frequent indication for biopsy and minimal change disease was the most common histopathological finding in our population.
