Author/Authors :
Kaul, Anupma Sanjay Gandhi Postgraduate Institute of Medical Sciences - Department of Nephrology, India , Sharma, Raj Kumar Sanjay Gandhi Postgraduate Institute of Medical Sciences - Department of Nephrology, India , Jaisuresh, Krishna Swamy Sanjay Gandhi Postgraduate Institute of Medical Sciences - Department of Nephrology, India , Agrawal, Vinita Sanjay Gandhi Postgraduate Institute of Medical Sciences - Department of Pathology, India
Abstract :
A 58-year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure. Investigations revealed marked peripheral eosinophilia and elevated perinuclear antineutrophil cytoplasmic antibody titers. Renal biopsy showed pauci-immune cre-scentic glomerulonephritis with interstitial eosinophil infiltrates. He had no history of asthma. Computed tomography of the chest and X-ray of the paranasal sinuses were normal. On Day 1,the patient developed ileal perforation. Resected ileal segments showed small vessel vasculitis with extravascular eosinophils. A diagnosis of non-asthmatic variant of Churg-Strauss syndrome was made. Renal recovery was achieved in 12 weeks with a combination therapy of corticosteroid and cyclophosphamide. The patient has been relapse-free for 12 months on oral prednisolone therapy.
