Skin level of microRNA‑369‑3P in patients with psoriasis and its correlation with disease severity

Background Psoriasis is a common autoimmune skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes. Recently, some microRNAs (miRs) have been proven to show an aberrant expression in psoriasis and may play a role in the pathogenesis of the disease. Objectives The aim of this study was to detect skin miR‑369‑3p levels in patients with psoriasis and its correlation with disease severity with measurement of one of its regulated psoriasis‑related genes, SIRT, and to find the correlation between the studied parameters. Patients and methods Skin tissues were collected, and skin miR‑369‑3p and SIRT1 gene levels were measured. The Psoriasis Area and Severity Index scores of patients and the correlation with skin miR‑369‑3p levels were evaluated. Correlation between miR‑369‑3p and SIRT1 gene was also evaluated. Results Skin miR‑369‑3p levels were higher in patients with psoriasis than those in healthy controls (P = 0.01). Skin miR‑369‑3p had an insignificant positive linear relation with Psoriasis Area and Severity Index scores in psoriasis patients (r = 0.079, P = 0.772). Insignificant negative correlation was found between miR‑369‑3p and SIRT1 gene levels in skin. Conclusion The expression of miR‑369‑3p is increased in skin tissues from psoriasis patients. Further studies are needed to clarify the role of miR‑369‑3p in the pathogenesis of psoriasis.