Author/Authors :
Sunder, Sham Post Graduate Institute of Medical Education and Research - Dr Ram Manohar Lohia Hospital - Department of Nephrology, India , Venkataramanan, K. Post Graduate Institute of Medical Education and Research - Dr Ram Manohar Lohia Hospital - Department of Nephrology, India , Verma, Himanshu Post Graduate Institute of Medical Education and Research - Dr Ram Manohar Lohia Hospital - Department of Nephrology, India , Bhardwaj, Minakshi Post Graduate Institute of Medical Education and Research - Dr Ram Manohar Lohia Hospital - Department of Pathology, India
Abstract :
A middle-aged female patient with a past history of non-alcoholic liver disease and hypothyroidism presented with swelling of the body,off and on,for six months and rapidly worsening renal function. Renal biopsy showed crescentic glomerulonephritis with negative immunofluorescence. Serological tests were positive for anti-thyroglobulin,anti-nuclear antibody (1:80),p-anti-neutrophil cytoplasmic antibodies; gamma globulin was 5.23 g/dL and viral markers were negative. The patient was diagnosed to have autoimmune hepatitis type-1 and treated with injection methylprednisolone pulse (500 mg/day for 3 days) and maintained on oral steroids and azathioprine 100 mg. She responded dramatically to this treatment and has remained in complete remission at last follow-up.
