Title of article :
Synthesis, Characterization, Electrochemistry and Antimicrobial Activity of Zinc(II) Complexes of some Hydrazone Schiff Bases
Author/Authors :
Ali, Hapipah M. university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Subramaniam, Puvaneswary university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Jefri Basirun, W. university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Zain, S.M. university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Abdullah, Noorlidah university of malaya - Faculty of Science - Institute of Biological Sciences, Malaysia , Teoh, H.L. university of malaya - Faculty of Science - Institute of Biological Science, Malaysia , Nazri, Loqman P.M. university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Syed Omar, Sharifah Rohaiza MARA University of Technology - Faculty of Science, Malaysia
Abstract :
A series of hydrazone Schiff bases and their zinc(II) complexes have been synthesized, characterized and evaluated for antimicrobial activity. The new zinc(II) complexes have been prepared in ethanol media by a template condensation of hydrazides, with either ketone or aldehyde and zinc(II) acetate in the presence of triethylamine. The IR, ¹H and ¹³C NMR data indicate that the hydrazone ligands are coordinated to zinc metal. The cyclic voltammetry of these zinc complexes exhibited irreversible oxidation peaks. The electro-oxidation of Zn2(Clhaptch)2(py)2 displayed a diffusion-controlled one electron transfer reaction process. The anti-microbial activity of the ligands and complexes were evaluated by plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi. There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi.
Keywords :
Hydrazone Schiff bases , zinc(II) complexes , cyclic voltammetry , anti , microbial activity
