Author/Authors :
Abdullah, Rosmiati , Rahman, Mawardi Universiti Putra Malaysia - Department of Chemistry, Malaysia , Ali, Abdul Manaf , Mohd Ismail, Hazar Bebe university of malaya - Centre for Foundation Studies in Science, Malaysia , Sukari, Mohd Aspollah Universiti Putra Malaysia - Department of Chemistry, Malaysia , Cheng Lian, Gwendoline Ee Universiti Putra Malaysia - Department of Chemistry, Malaysia , Kulip, Julius Forest Department, Malaysia
Abstract :
Detailed investigation on the leaves and barks of Glycosmis chlorosperma has led to the isolation and identification of a chalcone, dihydroglychalcone (1) and three sulphones -dambullin (2), sakambullin (3) and methylgerambullin (4), along with the common triterpene, stigmasterol. Compounds (1) (2) and (3) showed cytotoxic activity towards CEM-SS T-lymphoblastic cell lines. However, only dambullin (2) showed activity against pathogenic bacteria and fungi . We wish to report the isolation and bioassay results of the crude extracts and pure compounds.
Keywords :
Glycosmis chlorosperma , Ruta ceae , antimicrobial , cytotoxic , antioxidant
