Author/Authors :
Hadi, A. Hamid A. university of malaya - Department of Chemistry, Malaysia , Hadi, A. Hamid A. National University of Uzbekistan - Department of Mechanics and Mathematics, Uzbekistan , Mukhtar, Mat Ropi university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Khoo, Choon Weel university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Abd. Azziz, Saripah Salbiah Syed Universiti Pendidikan Sultan Idris - Faculty of Science and Technology - Department of Chemistry, Malaysia , Awang, Khalijah university of malaya - Faculty of Science - Department of Chemistry, Malaysia
Abstract :
Three alkaloids were isolated from the bark of Dehaasia candolleana (Meisn.) Kosterm; one morphinandienone, (-)-sebiferine 1 and two bisbenzylisoquinoline alkaloids namely (-)- O,O-dimethylgrisabine 2 and grisabine 3. Structural elucidations of these alkaloids were performed using spectroscopic methods notably 1H, 13C-NMR (ID and 2D) and compared with reported data. Alkaloids 1 and 2 exhibited potent in vitro antiplasmodial activities to two strains of P. falciparum-, D10 strain (sensitive strain) and Gombak A isolate (resistant strain).
Keywords :
Dehaasia candolleana , Lauraceae , morphinandienone , bisbenzylisoquinoline
