Author/Authors :
Habib, S. King Saud University - College of Medicine and King Khalid University Hospital - Department of Physiology, Saudi Arabia , Abba, Abdullah A. King Saud University - College of Medicine - Department of Medicine, Saudi arabia , Al-Zoghaibi, Mohammed A King Saud University - College of Medicine - Departments of Physiology, Kingdom of Saudi Arabia , Subhan, Mirza M. persian gulf university - College of Medicine Medical Sciences, بوشهر, ايران
Abstract :
Objectives: To determine the reference values of the fraction of exhaled nitric oxide (FENO) among healthy, non-smoking male adults and its correlation with age, height, weight, and body mass index (BMI).Methods: This cross-sectional study was conducted at the Departments of Physiology and Medicine, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, from September 2007 to August 2008 on healthy non-atopic, non-smoking male Saudi subjects. The FENO was measured online using the single-breath technique according to recent guidelines of the American Thoracic Society (ATS).Results: We studied 121 subjects with a mean age of 31.00±12.24 years, BMI of27.23±6.64, and FEV1/FVC 85% (81-92%). The FENO ranged between 7.66 parts per billion (ppb) and 46.6 ppb (mean 22.79±8.13), with 84% of subjects recording levels 30 ppb and 95% with levels 40 ppb. The FENO negatively correlated with body weight (r=0.3888, / =0.001) and BMI (r=0.238, ^ =0.009). No correlation was observed between FENO, FEV1/FVC ratio, age, and height.Conclusion: The reference values of FENO for nonsmoking, non-atopic male Saudi adults fall between 7.66 and 46.6 ppb (mean 22.79±8.13), similar to other populations. The FENO negatively correlates with body weight and BMI.
