Author/Authors :
Mehrabani, Davood Nemazee Hospital - Gastroenterohepathology Research Center - Department of Pathology, Shiraz , Rezaee, Aminallah shiraz university of medical sciences - Comparative Medicine Research Center - Departments of Internal Medicine, شيراز, ايران , Azarpira, Negar shiraz university of medical sciences - Comparative Medicine Research Center - Departments of Pathology, شيراز, ايران , Fattahi, Mohammad R. Nemazee Hospital - Gastroenterohepathology Research Center - Department of Pathology, Shiraz , Amini, Masoud shiraz university of medical sciences - Comparative Medicine Research Center - Departments of Surgery, شيراز, ايران , Tanideh, Nader shiraz university of medical sciences - Comparative Medicine Research Center - Departments of Pharmacology, شيراز, ايران , Panjehshahin, Mohammad R. shiraz university of medical sciences - Comparative Medicine Research Center - Departments of Pharmacology, شيراز, ايران , Saberi-Firouzi, Mehdi Nemazee Hospital - Gastroenterohepathology Research Center - Department of Pathology, Shiraz
Abstract :
Objectives: To determine the healing effect of Teucrium polium (T. polium) in indomethacin-induced gastric ulcer in rats. Methods: In the fall of 2007, 250 Sprague-Dawley rats provided by the Shiraz University Laboratory Animal Center were divided into 4 equal groups including control (70 rats), and 3 experimental groups (60 rats each), and each group received different doses of T. polium. Ten rats were used to study the induction of gastric ulcer by indomethacin (25 mg/kg/stat). After 24 hours, their stomachs were evaluated for any mucosal ulcer. The T. polium extract was administered orally, 24 hours after indomethacin administration. In the experimental group, 10 animals were sacrificed after 24, 48, and 72 hours, after administration of T. polium, and at one, 2, and 4 weeks, and in the control group identically after the administration of distilled water. Results: In rats treated with indomethacin, multiple ulcers were evident. After 4 weeks of treatment with T. polium, more re-epithelialization, proliferation, mucosal hyperplasia, migration of the gastric epithelial cells, and decrease in inflammatory cells were observed. The T. polium reduced the ulcer indices by 50% after one week, 80% after 2 weeks, and 90% after 4 weeks. Conclusion: The healing effect of T. polium may be due to antioxidant activity along with the ability to modulate the mucin secretion, prostaglandin synthesis, and epidermal growth factor receptor expression. These results along with the non-toxicity properties of T. polium suggests it as a promising anti- ulcer compound.
