Title of article :
Pheochromocytoma, papillary thyroid carcinoma
Author/Authors :
Nasser, Tariq King Khalid National Guard Hospital - Department of Medicine,Division of Endocrinology, Saudi Arabia , Qari, Faiza King Abdul-Aziz University Hospital - Princess Al-Jawhara Center for Excellence in Research of Hereditary Disorders - Division of Endocrinology and Internal Medicine, Saudi Arabia
Abstract :
A 53-year-old woman presented with labile and difficult to control hypertension on 3 different anti- hypertensive medications. Abdominal computed tomography and ultrasonography of the thyroid gland showed a 1.8 cm thyroid nodule. Fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. Serum thyroid stimulating hormone and free thyroxine, calcitonin, carcinoembryonic antigen, intact parathyroid hormone, and calcium levels were within normal limits. A 24-hour urine metanephrine showed significant elevation in urine metanephrine of approximately 3 times the upper limit of normal, and the result of 131I-metaiodobenzyleguanjdjne (131I- MIBG) scintography confirmed that the adrenal mass was pheochromocytoma. Right adrenalectomy and total thyroidectomy were performed. The final pathology was pheochromocytoma and papillary thyroid carcinoma. An analysis of c-ret porto- oncogene mutation yielded a negative result. This unusual association of 2 tumors represents a new entity.
Journal title :
Saudi Medical Journal
Journal title :
Saudi Medical Journal