Title of article
Metformin-induced Lactic Acidosis Associated with Multiorganic Failure
Author/Authors
Bolleku, Eriola University Hospital Center (UHC) “Mother Teresa” - Service of Nephrology, Albania , Idrizi, Alma University Hospital Center (UHC) “Mother Teresa” - Service of Nephrology, Albania , Barbullushi, Myftar University Hospital Center (UHC) “Mother Teresa” - Service of Nephrology, Albania , Bajrami, Valbona University Hospital Center (UHC) “Mother Teresa” - Service of Nephrology, Albania , Likaj, Ermal University Hospital Center (UHC) “Mother Teresa” - Service of Cardiosurgery, Albania , Thereska, Nestor University Hospital Center (UHC) “Mother Teresa” - Service of Nephrology, Albania , Ohri, Ilir University Hospital Center (UHC) “Mother Teresa” - Intensive Care Unit, Albania , Nunci, Lordian University Hospital Center (UHC) “Mother Teresa” - Intensive Care Unit, Albania
From page
381
To page
382
Abstract
Lactic acidosis is a rare but severe complication in patients with type 2 diabetes treated with metformin. Patients with lactic acidosis show commonly signs of shock, tissue hypoxia, acute hepatic or renal failure and the link between metformin therapy and lactic acidosis may be coincidental, associated or causal. Excessive plasma metformin concentrations show that lactic acidosis is due to a toxicological mechanism. We report a case of severe multiorganic failure in a subject after treatment with high doses of metformin.
Keywords
Metformin , Lactic acidosis , Multiorganic failure , Tissue hypoxia
Journal title
Medical Archives
Journal title
Medical Archives
Record number
2681709
Link To Document