Author/Authors :
Hodzic, Emir University Clinical Centre Tuzla - Clinic for Internal Diseases - Department of Nephrology and Dialysis, Bosnia andHerzegovina , Brcic, Majda University Clinical Center Tuzla - Clinic for Internal Diseases, Bosnia and Herzegovina , Atic, Mirza University Clinical Center Tuzla - Clinic for Internal medicine, Bosnia and Herzegovina , Halilcevic, Alma University Clinical Centre Tuzla - Clinic for Internal Diseases, Bosnia and Herzegovina , Jasarevic, Amila University Clinical Center Tuzla - Clinic for Internal Diseases, Bosnia and Herzegovina , Aleckovic-Halilovic, Mirna University Clinical Center Tuzla - Clinic for Internal Diseases, Bosnia and Herzegovina , Trojak, Davor University Clinical Center Tuzla - Clinic for Internal Diseases, Bosnia and Herzegovina , Atic, Nedima University Clinical Center Tuzla - Clinic for Diseases of Children, Bosnia and Herzegovina , Zulic, Snezana University Clinical Center Tuzla - Clinic for Diseases of Children, Bosnia and Herzegovina , Mehmedovic, Zlatan University Clinical Center Tuzla - Clinic for Surgery, Bosnia and Herzegovina , Iveljic, Ivana University Clinical Center Tuzla - Clinic for Internal Diseases, Bosnia and Herzegovina
Abstract :
Although kidney transplantation is by far the best method of renal replacement therapy, organ receiver is still not spared of eventual toxic consequences of drugs that are in charge of keeping the transplanted kidney functional. Both calcineurin inhibitors, of which tacrolimus more often, occasionally lead to neurotoxic side effects, mostly mild and reversible and dose-dependent in nature, but they can also be very severe or even fatal. It is very important to be aware of possible neurotoxic effects, to confirm them radiologically, and to prevent or reduce drug effects on nervous system. Sometimes the reduction of dose or substitution with another drug with similar mechanism effect is sufficient to terminate the neurotoxic effects of the drug and still not jeopardize the function of transplanted organ.
