Title of article
TRAIL TO INDUCE PSORIATIC SKIN LESION IN THE SKIN OF BALB/C MICE BY INJECTION OF STAPHYLOCOCCUS AUREUS EXOTOXIN
Author/Authors
JASSIM, HANADI A. University of Basrah - College of Medicine - Department of Microbiology, Iraq , BAKR, SUNDUS S. University of Basrah - College of Medicine - Department of Microbiology, Iraq , HAMDI, KHALIL I. University of Basrah - College of Medicine - Department of Medicine, Iraq
From page
163
To page
172
Abstract
An In Vivo attempt to induce psoriatic lesions in the skin of BALB/C mice by injection of bacterial superantigen. Staphylococcus aureus that was isolated from skin lesions of psoriatic patients was subjected to gel filtration chromatography for extraction and purification of their exoproteins. The skin of BALB/C mice was injected by 0.2 ml of the extracted purified exotoxin. The induced lesions were markedly similar to that of human psoriatic lesions, although the histopathological changes were not completely mirrored to that of human psoriatic skin lesions. There is an important role of Staph. aureus exotoxine (superantigen) in induction, triggering and maintenance of psoriatic lesions.
Keywords
Staphylococcus aureus , psoriasis , superantigens , animal model.
Journal title
Medical Journal of Islamic World Academy of Sciences
Journal title
Medical Journal of Islamic World Academy of Sciences
Record number
2682571
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