Title of article
Design of a novel bilayered gastric mucoadhesive system for localized and unidirectional release of lamotrigine
Author/Authors
Mohana Raghava Srivalli, K. Osmania University - G Pulla Reddy College of Pharmacy - Department of Pharmaceutics, India , Mohana Raghava Srivalli, K. Research and Development Centre, India , Lakshmi, P.K. Osmania University - G Pulla Reddy College of Pharmacy - Department of Pharmaceutics, India , Balasubramaniam, J. Research and Development Centre, India
From page
45
To page
52
Abstract
Lamotrigine is a BCS class II drug with pH dependent solubility. The bilayered gastric mucoadhesive tablets of lamotrigine were designed such that the drug and controlled release polymers were incorporated in the upper layer and the lower layer had the mucoadhesive polymers. The major ingredients selected for the upper layer were the drug and control release polymer (either HPMC K15M or polyox) while the lower MA layer predominantly comprised of Carbopol 974P. A 23 full factorial design was constructed for this study and the tablets were optimized for parameters like tablet size, shape, ex vivo mucoadhesive properties and unidirectional drug release
Keywords
Lamotrigine , Bilayered gastric mucoadhesive tablets , 23 full factorial design , Methacrylic polymers , Modified basket dissolution model , Zero order release , Unidirectional drug release
Journal title
Saudi Pharmaceutical Journal(SPJ)
Journal title
Saudi Pharmaceutical Journal(SPJ)
Record number
2684457
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