Her-2/Neu, Estrogen and Progesterone Receptor Expression In WHO Grade I Meningiomas

Objectives: Meningiomas are generally benign central nervous system neoplasms, which frequently express progesterone receptor (PR) and rarely express theestrogen receptor (ER). The significance of Her-2/neu expression in meningiomas is unclear. We evaluated the correlation with Her-2/neu, PR, ER expressions and clin-icopathologic parameters in World Health Organization (WHO) Grade I meningiomas. Patients and Methods: In total, 53 cases of menin- giomas were included in this study. Formaline-fixed, paraffin-embedded tissue sections were immunostained for Her-2/neu, PR and ER. Results: Whereas 27 (50.9%) of meningiomas were positive for PR, no reaction was determined for ER. Her-2/neu overexpression was observed in 12 (22.6%) cases. There was positive correlation between Her-2/neu and PR expressions (p=0.015). Her-2/neu expres-sion was frequently seen in meningothelial type (p=0.03). There were no correlations with Her-2/neu, ER, PR and other clinicopathologic parameters. Conclusion: The results of our study show that despitethere being PR expression at a high rate in grade I meningiomas, ER expression is a rare finding. Moreover, Her-2/neu expression has been detected more often in the PR positive and meningothelial type.