Author/Authors :
Uras, Nurdan Department of Neonatology Division - Medical Faculty of Fatih University, both in Ankara , Karadağ, Ahmet Department of Neonatology Division - Medical Faculty of Fatih University, both in Ankara , Tonbul, Alparslan Department of Neonatology Division - Medical Faculty of Fatih University, both in Ankara , Kara, Semra Department of Neonatology Division - Medical Faculty of Fatih University, both in Ankara , Tatlı, Mustafa Mansur Department of Neonatology Division - Medical Faculty of Fatih University, both in Ankara , Mete, Emin Department of Pediatrics - Medical Faculty of Fatih University, both in Ankara , Karabel, Musemma Department of Pediatrics - Medical Faculty of Fatih University, both in Ankara
Abstract :
Objectives: The aim of this study was to evaluatethe role of serum interleukin-6 (IL-6) levels in thedifferentiation of neonatal bacterial sepsis and TTN. Patients and Methods: The hospital records of 58newborns with respiratory distress that were above 35weeks of gestational age were investigated. Patientswere divided into two groups. The infection groupconsisted of patients with proven sepsis and clinicalsepsis and the remaining one was TTN group. Clinicalfindings and white blood cell count, serum C-reactiveprotein (CRP), IL-6 levels and the ratio of immatureneutrophils to total neutrophils count (I/T) were record-ed and were compared between the two groups. Results: Serum CRP and IL-6 levels were found higher than normal limits in both of the groups.However there was no significant difference betweenthem. Duration of respiratory distress was longer andI/T ratio was significantly higher in the infection groupthan TTN group. Conclusion: I/T ratio and IL-6 may contribute to theearly diagnosis of sepsis with respiratory symptomsin newborn but IL-6 alone can not distinguish TTNand sepsis.
Keywords :
Interleukin 6 , sepsis , newborn , transient tachypnea.
