Author/Authors :
Deepa, Mathiyalagan Department of Laboratory Medicine - Raajam Hospital, Karruppur, Tamil Nadu, India , Pasupathi, Palanisamy Department of Laboratory Medicine - Raajam Hospital, Karruppur, Tamil Nadu, India , Sankar, K.B. Vidhya Department Radiology - Raajam Hospital, Karruppur, Tamil Nadu, India , Rani, P Department Gynecology - Raajam Hospital, Karruppur, Tamil Nadu, India , Satish Kumar, S.P Department Diabetologe - Raajam Hospital, Karruppur, Tamil Nadu, India
Abstract :
In this study we investigated the oxidative stress, antioxidants and inflammatory molecules in patients of acute myocardial infarction (AMI) with diabetes (n=50) and non-diabetes (n=50). Fifty healthy subjects were taken as control. The levels of plasma TBARS and ceruloplasmin levels were significantly high in diabetic and non-diabetic AMI patients as compared with control. On the other hand, the activities of both enzymatic and non-enzymatic antioxidants were significantly decreased in diabetic and non-diabetic AMI patients as compared with control. Inflammatory markers showed significant rise in diabetic patients as compared with controls. Our results show increased inflammation and oxidative stress in patients with AMI, and magnitude of imbalance is greater in diabetic AMI patients, possibly because of greater inflammation in diabetic patients
Keywords :
Acute myocardial infarction , Antioxidant , Free radical , Diabetes mellitus
