Title of article :
Sperm Associated Antigens: Vigorous Influencers in Life
Author/Authors :
Faraji ، Samaneh Department of Molecular and Cellular Biology, Department of Embryology - Faculty of Basic Science and Advanced Technologies in Biology, Academic Center for Education, Culture and Research (ACECR), Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine - University of Science and Culture , Sharafi ، Mohsen Department of Embryology - Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine - Academic Center for Education, Culture and Research (ACECR) , Shahverdi ، Abdolhossein Department of Embryology - Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine - Academic Center for Education, Culture and Research (ACECR) , Fathi ، Rouhollah Department of Embryology - Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine - Academic Center for Education, Culture and Research (ACECR)
Abstract :
Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm s function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.
Keywords :
Antigen , Cancer , Fertility , Human , Sperm
Journal title :
Cell Journal (Yakhteh)
Journal title :
Cell Journal (Yakhteh)
