Title of article :
Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review
Author/Authors :
Babaye Abdollahi ، Behnaz Department of Medical Physics - Drug Applied Research Center, School of Medicine, Student Research Committee - Tabriz University of Medical Sciences , Malekzadeh ، Reza Department of Medical Physics - School of Medicine - Tabriz University of Medical Sciences , Pournaghi Azar ، Fatemeh Department of Operative Density - Dental and Periodontal Research Center - Tabriz University of Medical Sciences , Salehnia ، Fatemeh Research Center for Evidence Based Medicine - Tabriz University of Medical Sciences , Naseri ، Ali Reza Radiotherapy Department - Imam Reza Educational Hospital - Tabriz University of Medical Sciences , Ghorbani ، Marjan Stem Cell Research Center - Tabriz University of Medical Sciences , Hamishehkar ، Hamed Drug Applied Research Center - Tabriz University of Medical Sciences , Farajollahi ، Ali Reza Department of Medical Physics, Radiotherapy Department - Drug Applied Research Center, School of Medicine, Imam Reza Educational Hospital - Tabriz University of Medical Sciences
Abstract :
In recent years, high atomic number nanoparticles (NPs) have emerged as promising radioenhancer agents for cancer radiation therapy due to their unique properties. Multi-disciplinary studies have demonstrated the potential of NPs-based radio-sensitizers to improve cancer therapy and tumor control at cellular and molecular levels. However, studies have shown that the dose enhancement effect of the NPs depends on the beam energy, NPs type, NPs size, NPs concentration, cell lines, and NPs delivery system. It has been believed that radiation dose enhancement of NPs is due to the three main mechanisms, but the results of some simulation studies failed to comply well with the experimental findings. Thus, this study aimed to quantitatively evaluate the physical, chemical, and biological factors of the NPs. An organized search of PubMed/Medline, Embase, ProQuest, Scopus, Cochrane and Google Scholar was performed. In total, 77 articles were thoroughly reviewed and analyzed. The studies investigated 44 different cell lines through 70 in-vitro and 4 in-vivo studies. A total of 32 different types of single or core-shell NPs in different sizes and concentrations have been used in the studies.
Keywords :
Nanoparticle , Radio , sensitization , Radiation therapy , Cancer
Journal title :
Advanced Pharmaceutical Bulletin
Journal title :
Advanced Pharmaceutical Bulletin
