The Relation of Copper and Zinc with Incidence of Neonatal Sepsis and Possible Prediction Biomarker Role

According to recent studies [1, 2], nutrition is believed to play a role in the pathogenesis of adverse pregnancy outcomes, including preterm birth and subsequent neonatal sepsis. Trace elements such as copper (Cu) and zinc (Zn) are essential for a pregnancy with good outcomes for both mother and infant. As a result, deficiency of these elements plays an important role in neonatal complications such as neonatal sepsis [3]. In other words, pregnant women, especially in developing countries, are considered a highrisk group for trace elements deficiency, especially Zn and Cu [4]. Previous studies have investigated the association between nutritional deficiencies with the risk of increased neonatal sepsis, but few studies have examined the status of these elements during neonatal sepsis and its association with disease severity [3, 4].