Title of article :
Anti-Rheumatic Drugs as Potential Anti-inflammatory, Immunomodulatory Agents against COVID-19: A Systematic Review
Author/Authors :
Sinaei ، Reza Department of Pediatrics - School of Medicine, Institute of Basic and Clinical Physiology Sciences, Endocrinology and Metabolism Research Center - Kerman University of Medical Sciences , Pezeshki ، Sara Department of Internal Medicine - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences , Asadipour ، Ali Pharmaceutical Sciences and Cosmetic Products Research Center - Kerman University of Medical Sciences , Shiari ، Reza Department of Pediatric Rheumatology - School of Medicine - Shahid Beheshti University of Medical Sciences , Sinaei ، Roya Department of Pediatrics - School of Medicine - Kerman University of Medical Sciences , Sinaei ، Ali School of Pharmacy - Kerman University of Medical Sciences
From page :
S13
To page :
S28
Abstract :
Background: The effective responses of both innate and adaptive immunity are crucial in combating novel coronavirus-2 infection. An excessive response may lead to cytokine storm, which is a challenging problem in therapeutic strategies. Methods: A systematic review was carried out by searching Ovid MEDLINE, PubMed, Google Scholar, and Cochrane library databases from inception, for anti-inflammatory and immunomodulatory drugs against coronavirus disease 2019 (COVID-19). Results: The results of the effectiveness of Hydroxychloroquine are just like a sinusoidal diagram and in a state of ambiguity. Thalidomide was effective in some cases but has not yet been proven. Low-dose Corticosteroids may be effective in the early stages of the illness as a bridge. There is no evidence of benefits or adverse outcomes for the use of non-steroidal anti-inflammatory drugs and Cyclosporine-A. In some critically ill patients, Interleukin-6 (IL-6) and IL-1 blockers and to some extent, Tumor-Necrosis-Factor-α and Janus-Kinase inhibitors are useful. Finally, high-dose intravenous immunoglobulin reversed the deterioration of patients in most trials. Conclusion: One strategy behind the treatments for COVID-19 is based on breaking the cytokine storm. Although avoiding the suppression of anti-viral immunity is crucial by choosing the weaker and more selective anti-inflammatories, some strategies are kept for hyper-inflammatory situations. Scheduling of treatment is also important. Although low-dose steroids may be effective in the early stages of the illness, “Tocilizumab” is more effective in severe situations, when the IL-6 level is high and other drugs are ineffective. Therefore, consideration should be given to each patient separately.
Keywords :
Antiinflammatory , Immunomodulatory , COVID , 19 , SARS , CoV , 2
Journal title :
Pharmaceutical Sciences
Journal title :
Pharmaceutical Sciences
Record number :
2687006
Link To Document :
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