Amitraz Toxicity in a Dog

This case investigated the changes in laboratory parameters in a two months old labrador crossbred dog with amitraz toxicity. Anamnesis revealed that the veterinarian had recommended a amitraz bath against tick infestations, but it had apparently been applied to the whole body for two consecutive days. Dog was brought to our clinic with complaints of vomitus, contraction, anorexia, and hypersalivation. Physical examination detected tonic and clonic convulsions, depression, pallor of conjunctiva mucosa, bradycardia, hyperthermia, and polypnoea. Hematological and biochemical analysis were also performed. Serum insulin and cortisol levels were, thus, measured. Microcytic hypochromic anemia and thrombocytosis were determined in haematology. Biochemical analysis showed that the levels of glucose, ALP, GGT, CK, and LDH increased, while those of the Na, Cl, and insulin decreased. As the treatment, fluid theraphy, atropine sulfate, diazepam, trimetobenzamid hydrochloride, and methyl prednisolone were administered for two days, and ferrosanol syrup were given for one week. Convulsions and vomiting diminished on the second day of the treatment. After the seven day of the treatment, the body temperature and heart and respiratory frequencies were found to be in the range of the reference value. Degree of the anemia lowered, but did not recover fully. The LDH and CK levels decreased, as compared to those before the treatment, but were still above the reference values. Although insulin levels were close to the lower limit of the reference values, glucose levels were close to the upper limits. The findings concluded that highlighting the levels of the glucose, insulin, CK, LDH, Na, and Cl may be useful in the evaluation of amitraz toxication in dogs.