The Effects of Sildenafil Citrate on Some Haematological Parameters and Mineral Matters in Wound Healing of Rats Created Experimental Diabetes

In this study, the effect of sildenafil citrate on some haematological parameters and mineral levels in the early stages of wound healing was investigated. Rats were randomly allocated into three treatment groups consisted of 10 rats in each. Groups were designed as control (group I), diabetic (group II) and diabetic plus sildenafil citrate (group III), respectively. Normal wound care was performed for control and group II. Sildenafil citrate was also administered with normal wound care for group III at 0.7 mg/kg dosage for 3 days via intraperitoneally (i.p.) once a day. Blood samples were collected before and at 1., 2., and., 3. days of after administration. Full blood erythrocyte (RBC), haemoglobin (HG), haematocrit (HCT) values were determined using standard methods; spectrophotometric methods were used for determination of the serum iron (Fe), manganese (Mn), copper (Cu), zinc (Zn), lead (Pb), potassium (K), calcium (Ca), and magnesium (Mg) levels. Sildenafil citrate increased the serum mineral levels (i.e. Zn, Cu and Mg), as having favourable impact on diabetic wound healing process. Likewise, it decreased the level of iron mineral, as having an adverse effect on the healing process. In conclusion, it was concluded that sildenafil citrate had a favourable effect on the healing process by shortening the inflammatory period, which is the first period of wound healing process.