Electrocatalytic Determination of Anti-Cancer Drug Imatinib, Using Ni Nanoparticle Modified Carbon Paste Electrode

In this research, nickel nanoparticles were synthesized by non-aqueous polyol method and morphology of nanoparticles was studied using scanning electron microscopy. Then Ni nanoparticle modified carbon paste electrode was prepared. Electrochemical behavior of modified electrode was studied in basic solution, using cyclic voltammetry and chronoamperometry methods. A pair of oxidation-reduction peaks relating to Ni(OH)2/ NiOOH redox couple was observed in cyclic voltammogram of this electrode. Also, the electrochemical behavior of this electrode in presence of imatinib drug was studied. Results show that this modified electrode has a good ability for electrocatalytic oxidation of imatinib in basic solution. In presence of imatinib, current intensity of oxidation peak of electrode was increased, depending on its concentration. Linear dynamic range, limit of detection and rate constant of electrocatalytic reaction were determined using cyclic voltammetry and chronoamperometry methods. Amount of limit of detection (LOD) in cyclic voltammetry and hydrodynamic amperometry methods were calculated 1.2 × 10 -6 M and 3.5 × 10-7M respectively. Finally, the proposed sensor was successfully applied for determination of imatinib in real samples such as tablet and human blood plasma.