Author/Authors :
Saleh, Mohammed M. University of Technology - college of science for wom - Chemistry Department, Iraq , AL-Joubori, Sabiha F- Foundation of Techical Education - college of health and Medical technology - Medical analysis Department, Iraq , AL- Thamiar, Boushra F Baghdad University - college of science for women - Chemistry Department, Iraq
Abstract :
Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2- amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4- thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4-thiadiazole, compound E: 2- amino-5- (2-Propanylthio)-1,3,4-thiadiazol) and compound F:2(o-chlorobenzylamino)-5-(2-propanyl thio)-1,3,4 thiadiazol. All prepared compounds were diagnosed by (IR) and (UV) Spectroscopy. All of those compounds were screened for their anti-microbial activity in vitro. The results show that most of the compounds A, B, C exhibited moderate to good activity against Gram-positive bacteria and the same compound exhibit low to moderate activity on most gram-negative bacteria under study. Finally, compound E and F had little or no effect organism
